One study looked at how Xgeva compared to a drug called zoledronic acid Zometa in people with bone metastasis from prostate cancer. The people had prostate cancer that spread to their bones. Multiple myeloma is a form of cancer that affects your bone marrow the tissue in your bones. The disease changes plasma cells, which are a kind of white blood cell that helps fight infections. These changed cells crowd out healthy cells.
Xgeva is used to help prevent broken bones in people with multiple myeloma. One study looked people with multiple myeloma or cancer that spread to their bones. Researchers studied how long it was until people had a fracture. A second study reported that the zoledronic acid group had a fracture at days.
The Xgeva group lasted to days before a fracture occurred. Breast cancer affects cells in the breast and causes them to divide and multiply. In some cases, the cancer can reach your bones. The drug is also used to treat other complications of cancer such as hypercalcemia of malignancy high levels of calcium. One study compared Xgeva to a drug called zoledronic acid Zometa in people with bone metastasis from breast cancer.
The people had breast cancer that spread to their bones. Of the people who took Xgeva, This was compared to Another study that lasted 6 years also looked at people with bone metastasis from breast cancer. They took either Xgeva or zoledronic acid.
People who took Xgeva had fractures, while people who took zoledronic acid had fractures. When cancer moves from a part of your body to your bones, the cancer cells can crowd out healthy bone cells. These bone cells release calcium , which moves into your bloodstream.
Too much calcium in your blood is called hypercalcemia. Xgeva is approved to treat hypercalcemia of malignancy. You must have already tried a type of drug called a bisphosphonate, which helps prevent the loss of bone mass. One clinical trial looked at people with hypercalcemia who took Xgeva.
In some cases, Xgeva is approved to treat certain tumors in adolescents whose bones have finished growing. In studies , adolescents who took Xgeva while their bones were still growing developed hypercalcemia after they stopped treatment. Hypercalcemia refers to high levels of calcium in your blood. Adolescents also developed hypercalcemia if they took Xgeva for off-label uses. Xgeva can interact with several other medications.
It can also interact with certain supplements as well as certain foods. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe. Below is a list of medications that can interact with Xgeva.
This list does not contain all drugs that may interact with Xgeva. Before taking Xgeva, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take.
Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. This can increase your risk for serious infections, especially if your immune system is already weak.
They may recommend different medications for you. Taking Xgeva and etelcalcetide can decrease the level of calcium in your blood. This can lead to hypocalcemia low level of calcium. If you have any symptoms of hypocalcemia while taking Xgeva, call your doctor right away.
This can increase your risk for serious infections. They may choose a different medication that does not interact with siponimod. Xgeva and Prolia both contain the same active ingredient, denosumab. This may cause an increased risk in side effects and more severe side effects such as hypercalcemia.
They may have you use one or the other drug, but not both. The two drugs are often used together to help treat some forms of breast cancer.
Although the tissue in your bones is constantly breaking down, your body builds the tissue back up, which helps keep your bones strong. A protein called RANKL usually help keep the process of breaking down bone and rebuilding bone in balance. This can cause the cancer cells to increase the breakdown of the bone, leaving bones weak and more likely to break.
Receptors are proteins on the outside of cells that act like docking stations. This is the way Xgeva works in helping prevent bone fractures and breaks in multiple myeloma and bone metastasis. The drug can also shrink the tumors. In addition, Xgeva helps treat hypercalcemia caused by cancer.
When bone is broken down and reabsorbed into the body, calcium levels rise. The end result is reduced calcium levels.
In clinical studies , within 1 week of starting treatment, most people who took Xgeva had a meaningful reduction in bone turnover markers in their blood. This is a sign that the drug is strengthening your bones.
In animal studies , Xgeva harmed the baby when the drug was given to the pregnant mother. Xgeva also harmed the baby when the mother was given the drug within the 5 months before they became pregnant.
Talk with your doctor about other treatment options. Women should also use birth control for at least 5 months after they stop taking Xgeva. This is in case they become pregnant during this time. In animal studies , Xgeva was found in breast milk. They can help you find the best way to feed your child. Xgeva is a targeted therapy.
This type of treatment targets cancer cells and tends to leave healthy cells alone. Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body. Chemotherapy drugs act on all cells in your body that are growing rapidly, not just cancer cells.
And both drugs contain the active ingredient denosumab. Drugs with the same active ingredient can be used for different things based on how much and how often you take them. And this could increase your risk for side effects such as osteonecrosis death of bone cells and hypocalcemia low levels of calcium. And if you have questions about Xgeva or Prolia, talk with your doctor or pharmacist.
You might. Along with the calcium supplements, your doctor may also prescribe vitamin D supplements. Vitamin D helps your bones absorb calcium. Tell your doctor if you notice any of them while taking the drug.
Of the two drugs, only Prolia is approved to treat osteoporosis in certain cases. Prolia is used for people who have a high risk of breaking their bones, including:. And if you have questions about Xgeva, Prolia, or how to treat osteoporosis, talk with your doctor. You can help do this by brushing and flossing every day, and seeing your dentist on a regular basis. Problems with your mouth, teeth, and jaw while taking Xgeva are often early warning signs of osteonecrosis in your jaw.
Keep in mind that certain dental procedures can put you at risk for problems such as slow healing or infection in your jaw.
These procedures include tooth extraction , root canal , and dental implant surgery. If you need minor dental surgery during Xgeva treatment, watch for any symptoms you have afterward. Tell your dentist if you have any pain or wounds in your mouth or jaw that are slow to heal. If you have questions about mouth and jaw problems while taking Xgeva, ask your dentist or doctor.
Before taking Xgeva, talk with your doctor about your health history. Xgeva may not be right for you if you have certain medical conditions or other factors affecting your health. These include:. Xgeva binds to the receptor activator of nuclear factor kappa-B ligand RANKL , a required protein for the formation of osteoclasts.
Increased osteoclast activity increases the risk of bone loss in people with solid tumors with metastasis. This binding results in the prevention of RANKL from binding with its receptor and doing its job of breaking down bone, thereby decreasing the risk of bone loss. The final result is decreased bone loss and increased bone density.
Doses of mg once every 4 weeks reach steady state by 6 months. In patients with giant cell tumor of bone and hypercalcemia of malignancy, doses of mg are needed on days 8 and 15 doses in addition to mg once every 4 weeks, and reach steady state in 3 months.
Store Xgeva in its original carton. Do not let the product freeze. Xgeva must be discarded if not used within 14 days of removal from refrigerator. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This article discusses what smoldering multiple myeloma is, diagnosis, treatment options, and outlook. A bone scan is an imaging technique that doctors use to diagnose bone diseases, infections, and fractures.
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Xgeva denosumab. Medically reviewed by Dena Westphalen, Pharm. What is Xgeva? Xgeva generic. Xgeva side effects. Xgeva cost. Xgeva dosage. Alternatives to Xgeva.
Xgeva vs. Xgeva uses. Xgeva and alcohol. Xgeva interactions. How Xgeva is given. How Xgeva works. Xgeva and pregnancy. Xgeva and birth control. Xgeva and breastfeeding. Common questions about Xgeva. Xgeva precautions. Professional information for Xgeva. Latest news Scientists identify new cause of vascular injury in type 2 diabetes. Adolescent depression: Could school screening help? Related Coverage. What to know about smoldering multiple myeloma.
Medically reviewed by Angelica Balingit, MD. What to know about nuclear bone scans. Ewing sarcoma: What to know Medically reviewed by Dr. Ana M. What could cause bone pain? Xgeva Injections products available Video. View by: Product Supplier. Location Near Me. Popular Xgeva Injection Products. Imperial Healthcare Private Limited. Apple Pharmaceuticals. Denosumab mg Xgeva Mg Injection, 1. Inspire Global. Denasumab Xgeva Injection, Amgen.
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